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Warning: date(): It is not safe to rely on the system's timezone settings. You are *required* to use the date.timezone setting or the date_default_timezone_set() function. In case you used any of those methods and you are still getting this warning, you most likely misspelled the timezone identifier. We selected the timezone 'UTC' for now, but please set date.timezone to select your timezone. in /home/volgostoma/domains/stom-portal.ru/public_html/plugins/content/extranews.php on line 589

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Warning: date(): It is not safe to rely on the system's timezone settings. You are *required* to use the date.timezone setting or the date_default_timezone_set() function. In case you used any of those methods and you are still getting this warning, you most likely misspelled the timezone identifier. We selected the timezone 'UTC' for now, but please set date.timezone to select your timezone. in /home/volgostoma/domains/stom-portal.ru/public_html/plugins/content/extranews.php on line 589

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Автор: Administrator   

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23.04.2011 18:02

Протеолизо-хелационная теория кариеса Шатца и Мартина (1956 г.)

Протеолизо-хелационная теория кариеса Шатца и Мартина (1956 г.). Авторы объясняли восприимчивость эмали к поражению кариесом ста­бильностью кальций-белковых комплексов. Эмаль зуба является неотъемлемой структурой организма, которая в силу функциональных особенностей минерализована больше, чем другие ткани. При этом минеральные и органические компоненты эмали находятся в тесной биохимической связи. Устойчивость последней может быть нарушена при проникновении в эмаль различных активных химических агентов, в том числе протеолических ферментов. Развитие кариозного процесса рассматривается в два этапа:

  • протеолиз, при котором происходит разрыв связей между белками и минералами эмали вследствие воздействия бактериальных протеолитических ферментов на белковые компоненты;
  • хелация, когда наблюдается разрушение минеральной части твер­дых тканей зуба из-за образования комплексных соединений ионов металлов с анионами кислот, солями органических кислот, амино­кислотами, белками и промежуточными продуктами распада.
Отрицательные стороны теории Положительные стороны теории
  1. В настоящее время нет дока­зательств первой фазы кариозного процесса по Шатцу —Мартину. При кариесе в стадии белого пятна ни нарушения ковалентных связей между органическими и неоргани­ческими веществами, ни распада белка не обнаружено.
  2. Недооценивается местное воздействие кислот, образующих­ся под зубной бляшкой, и переоце­нивается хелацнонный метод деми­нерализации эмали, который идет очень медленно, в то время как раз­рушение твердых тканей зуба иног­да происходит весьма интенсивно.
  3. Теория не объясняет лока­лизацию кариеса, частоту пораже­ния определенных поверхностей зуба.
  1. Восприимчивость эмали к поражению кариесом авторы объясняли стабильностью каль­ций-белковых комплексов.
  2. Теория содержит научное обоснование действия хелатов на эмаль зуба, то есть некислотной деминерализации твердых тканей зуба при нейтральной или даже ще­лочной среде полости рта, что не­обходимо учитывать в патогенезе кариеса любой этиологии.

При оценке данной теории следует отметить, что она не отвечает на ряд важных вопросов и посему не нашла широкого распростране­ния, однако в силу обстоятельности пополнила архив теорий кариеса, каждая из которых создавалась с учетом накопленных в свое время достижений науки.


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Обновлено 16.07.2011 16:05
 
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